Homeostatic proliferation of intestinal intraepithelial lymphocytes precedes their migration to extra-intestinal sites

Migration of intestinal intraepithelial lymphocytes into a polarized epithelial monolayer.

Intraepithelial lymphocytes (IEL) are a phenotypically distinct population of lymphocytes that reside in mucosal epithelia, below the intercellular tight junctions. Although adhesive functions of this population have been previously studied, relatively little is known about IEL migration from the microvasculature into the epithelium. We demonstrated that cultured human IEL were capable of migra...

Cell Density Counts of the Intestinal Intraepithelial Lymphocytes in the Celiac Patients

Background: Increased number of intestinal intraepithelial lymphocytes (IELs) is a key histological finding in the diagnosis of celiac disease (CD); however, the number of IELs in celiac patients and healthy subjects may vary from one region to another. Additionally, there are some seronegative celiac patients with a borderline histology. Objective: To determin...

Intestinal intraepithelial lymphocytes: the plot thickens

O ver the last few years, the characterization of T lyraphocytes within the intestinal epithelium (ilEL) has revealed phenotypic and functional heterogeneity that rivals only that observed within the thymus. Of note in this context is that thymic and intestinal epithdia share the same embryologic origin in that they are both derived from endoderm. Several lines of evidence have led to the concl...

Homeostatic Proliferation of Lymphocytes

Epithelia by B Lymphocytes Homeostatic Regulation of Intestinal Villous